A unique society dedicated to advancing vision care and improving patients' quality of life through Innovation, Education and Advocacy.

upcoming meetings

AECOS Winter Symposium
Feb 25 - 28, 2018 | St. Regis, Aspen, CO

AECOS European Symposium
May 31 - June 3, 2018 | Berlin, Germany

AECOS Summer Symposium
July 12 - 15, 2018 | St. Regis Hotel, Deer Valley, UT

the corneal cross linking initiative

Principal Investigators in the AECOS Corneal Cross-Linking Study

AECOS Sponsored Clinical Trials

AECOS Corneal Cross-Linking Clinical Trial

AECOS™ (American-European Congress of Ophthalmic Surgery) is pleased to sponsor a leading accelerated cross-linking study, ACOS-KXL-001, in which 100 clinical sites will offer accelerated cross-linking throughout the US. AECOS™ received approval from the FDA to initiate a phase 3, multicenter, randomized, controlled evaluation of the safety and efficacy of corneal collagen cross-linking in eyes with keratoconus or corneal ectasia after refractive surgery. AECOS™ is sponsoring the study, and Avedro, inventor of accelerated cross-linking, will conduct it. The study exclusively utilizes Avedro’s riboflavin and KXL system for accelerated cross-linking.

Patients with keratoconus and corneal ectasia will be recruited nation-wide at 100 clinical trial sites to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with Avedro’s riboflavin and KXL System for reducing corneal curvature. Patients will be randomized to one of three treatment groups by active treatment condition (keratoconus or corneal ectasia). The study will enroll 2,000 study eyes with keratoconus and 2,000 study eyes with corneal ectasia following refractive surgery, and all fellow eyes that meet the criteria will have access to treatment. Three doses of irradiation will be tested: 15 mW/cm2 for 8 minutes, 30 mW/cm2 for 4 minutes, and 45 mW/cm2 for 2 minutes and 40 seconds. All study eyes will be treated, and all treatments will be performed with the epithelium removed.

Corneal collagen cross-linking has been commonly used as the first-line method to restore corneal stability in keratoconic and corneal ectatic eyes in Europe and throughout the world for over 13 years. The traditional therapy for cross-linking involves the application of a riboflavin solution to the eye for 30 minutes, followed by 30 minutes of UVA exposure at 3 mW/cm2. Avedro recently submitted an NDA to the US FDA for a cross-linking study at these parameters, and is starting two new trials in which accelerated cross-linking will be evaluated.

Principal Investigators: AECOS Corneal Cross-Linking Clinical Sites:

Aran Alberto The Laser Center of Coral Gables Coral Gables, FL 305-461-0003
Ashford William Eye Surgery and Laser Center Jackson, MS 601-985-9120
Ayres Brandon Ophthalmic Partners of PA, P.C. Bala Cynwyd, PA 484-434-2700
Bagan Steven Bagan Strinden Vision Fargo, ND 701-293-8242
Batra Nicholas Batra Vision Medical Group San Leandro, CA 510-276-1212
Beckman Kenneth Comprehensive Eye Care of Central Ohio Westerville, OH 614-890-5692
Boland Thomas Northeastern Eye Institute Scranton, PA 800-334-2233
Braverman Stanley Braverman Eye Center Hallandale, FL 1-888-954-LASIK
Bucci Frank A. Bucci Laser Vision Institute Wilkes-Barre, PA 570-825-5949
Chamberlain Winston Casey Eye Institute/OHSU Portland, OR 503-494-3000
Chu Y. Ralph Chu Vision Institute Bloomington, MN 866-400-EYES
Chung Gary Evergreen Eye Center Federal Way, WA 800-254-4934
Clinch Thomas Eye Doctors of Washington Chevy Chase, MD 877-SEE WITH LASIK
Dell Steven J. Dell Laser Consultants Austin, TX 512-347-0255
Desai Neel The Eye Institute of West Florida Largo, FL 727-581-8706
Doe Erin Berkeley Eye Center Houston, TX 713-526-3937
Dunn Steven Michigan Cornea Consultants, PC Southfield, MI 248-350-1130
Ellis Dean Kansas LasikPlus, P.A. Leawood, KS 866-921-2392
Fintelmann Robert Barnet Dulaney Perkins Eye Center Phoenix, AZ 866-742-6581
Fram Nicole Advanced Vision Care Los Angeles, CA 310-229-1220
Gangadhar Dasa Grene Vision Group Wichita, KS 316-684-5158
Gira Joseph P. Ophthalmology Consultants Des Peres, MO 314-909-0633
Gordon Richard Ramapo Ophthalmology Associates, LLP Pomona, NY 845-362-1450
Grace Colleen Henry Ford Health System Detroit, MI 800-436-7936
Greenberg Jason LasikPlus Vision Center Louisville, KY 866-921-2392
Greiner Mark University of Iowa Hospitals and Clinics Coralville, IA 319-467-2000
Groden Lewis LCA-Vision Inc. Tampa, FL 813-639-3937
Herschel Mark Herschel Lasik Orlando, FL 407-894-8081
Himmel Kenneth Eye Associates of New Mexico Albuquerque, NM 505-883-6800
Ing Jeffrey Delta Eye Medical Group Stockton, CA 209-478-1797
Iuorno Joseph D. Commonwealth Eye Associates Richmond, VA 804-740-7474
Jain Vivek Beach Eye Care Virginia Beach, VA 757-425-5550
Jones Michael Paul Illinois Eye Surgeons Belleville, IL 618-234-1774
Khachikian Stephen Black Hills Regional Eye Institute Rapid City, SD 605-341-2000
Kuck Paul Gundersen Clinic, Ltd. La Crosse, WI 608-775-2191
Kugler Lance Kugler Vision, PC Omaha, NE 402-558-2211
Labor Phillips Eye Consultants of Texas Grapevine, TX 817-410-2030
Lehmann James Focal Point Vision San Antonio, TX 210-614-3600
Liang Keith Center for Sight Sacramento, CA 916-446-2020
Loden James Loden Vision Centers Goodlettsville, TN 615-859-3937
Manche Edward Stanford University School of Medicine Palo Alto, CA 650-498-7020
Melki Samir Boston Eye Group Brookline, MA 617-566-0062
Meskin Seth Eye Physicians and Surgeons, PC Milford, CT 203-878-1236
Mian Shahzad University of Michigan Ann Arbor, MI 734-763-8122
Miedziak Anita Princeton Eye Group Princeton, NJ 609-921-9437
Mishra Gautam Schein Ernst Eye Associates Harrisburg, PA 717-233-3937
Moshirfar Majid University of Utah Dept. of Ophthalmology & Visual Sciences Salt Lake City, UT 801-581-2352
Newman Leonard Newman Lasik Centers Sacramento, CA 916-256-1900
Orlin Stephen E. Scheie Eye Institute, University of Pennsylvania School of Medicine Philadelphia, PA 215-662-9062
Paglen Patrick Kaiser Permanente Santa Rosa, CA 707-566-5232
Parker John John Parker, MD (private office) Birmingham, AL 205-933-1077
Pepose Jay Pepose Vision Institute / Lifelong Vision Foundation Chesterfield, MO 636-728-0111
Petashnick Daniel Manchester Ophthalmology Manchester, CT 860-649-5177
Pramanik Sudeep GBMC Dept. of Ophthalmology/Mid-Atlantic Cornea Consultants Towson, MD 443-849-2106
Raizman Michael Ophthalmic Consultants of Boston Waltham, MA 781-487-2200
Ramirez Ruben Buena Vista Eyecare El Paso, TX 915-630-6463
Rapuano Christopher Corneal Associates, PC at Wills Eye Institute Philadelphia, PA 215-928-3180
Richheimer William Mile High Corneal Specialists, PC Denver, CO 303-482-1300
Rivera Lilia Lilia Rivera, MD San Juan, P.R. 7872507746
Rivera Robert P. Hoopes Vision Draper, UT 855-570-2949
Rosenfeld Steven Delray Eye Associates, PA Delray Beach, FL 561-498-8100
Shah Pulin Ochsner Medical Center New Orleans, LA 504-899-9311
Shah Ravindra A. Eyecare Medical Group Portland, ME 888-374-2020
Sheppard John Virginia Eye Consultants Norfolk, VA 757-622-2200
Shih Carolyn North Shore LIJ Health Systems Great Neck, NY 516-708-2540
Sierra Patricia Grutzmacher, Lewis and Sierra Sacramento, CA 916-649-1515
Silk Wesam Silk Vision & Surgical Center Annandale, VA 703-876-9700
Slade Stephen Slade and Baker Vision Center Houston, TX 713-626-5544
Smith Byron The Eye Clinic Surgicenter Billings, MT 406-252-6608
Solomon Jonathan Solomon Eye Physicians & Surgeons Bowie, MD 301-464-1885
Stevens Garth Eye Care Center of Virginia Richmond, VA 804-343-2020
Stone Donald Dean McGee Eye Institute Oklahoma City, OK 405-271-6060
Straiko Michael Devers Eye Institute Portland, OR 503-413-8202
Sutton Gregory Eye Surgical Associates Lincoln, NE 800-742-2224
Thompson Vance Vance Thompson Vision Sioux Falls, SD 605-361-3937
Verdier David Verdier Eye Center, P.L.C Grand Rapids, MI 616-949-2001
Vukich John Dean Foundation for Health, Research and Education, Inc. Madison, WI 608-282-2000
Wang Ming Xu Wang Vision Institute Nashville, TN 615-321-8881
Weisenthal Robert CNY Eye Care Syracuse, NY 315 445 1577
Wellish Kent Wellish Vision Institute Las Vegas, NV 702-733-2020
Wolsey Darcy The Eye Institute of Utah Salt Lake City, UT 800-760-4171
Woodcock Michael Carolina Vision Center Fayetteville, NC 910-485-3937
Wright Paul Wright Vision Center Rapid City, SD 877-576-0202